Recent Publications

June - September 2025

Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis-induced cytokine transcriptional responses. 

Ivie JJ, Dill-McFarland KA, Simmons JD, Peterson GJ, Benchek PH, Mayanja-Kizza H, Veith LE, Agata M, Ha DT, Nghia HD, Boom WH, Stein CM, Khor CC, Thwaites GE, Hai HT, Thuong NT, Chang X, Dunstan SJ, Hawn TR.J Clin Invest. 2025 May 22;135(14):e179822. doi: 10.1172/JCI179822. eCollection 2025 Jul 15.PMID: 40402573 

  

Combined dolutegravir and tuberculosis preventive therapy. 

Muzanyi G, Mayanja-Kizza H.Lancet HIV. 2025 Jun;12(6):e395-e397. doi: 10.1016/S2352-3018(25)00069-4. Epub 2025 May 8.PMID: 40349708 No abstract available. 

 

Diagnostic accuracy of self-collected tongue swabs for Mycobacterium tuberculosis complex detection in individuals being assessed for tuberculosis in South Africa using the Xpert MTB/RIF Ultra assay. 

David A, Singh L, Peloakgosi-Shikwambani K, Nsingwane Z, Molepo V, Cangelosi G, da Silva P, Stevens W, Scott L.Clin Microbiol Infect. 2025 Jun;31(6):1040-1045. doi: 10.1016/j.cmi.2025.01.029. Epub 2025 Jan 28.PMID: 39884504  

  

Common Biological Properties of Mycobacterium tuberculosis MmpL3 Inhibitors. 

Ames L, Allen R, Boshoff HIM, Cleghorn LAT, Engelhart CA, Schnappinger D, Parish T.ACS Infect Dis. 2025 Sep 12;11(9):2523-2533. doi: 10.1021/acsinfecdis.5c00394. Epub 2025 Aug 19.PMID: 40827527  

  

New Triazolopyrimidines with Improved Activity against Mycobacterium tuberculosis. 

Pogula SR, Deshpande A, Greve E, Chowdhury S, Parish T.ACS Med Chem Lett. 2025 May 1;16(6):1008-1016. doi: 10.1021/acsmedchemlett.5c00073. eCollection 2025 Jun 12.PMID: 40529071 

  

Thienopyrimidine amide analogs target MmpL3 in Mycobacterium tuberculosis. 

Baldin VP, Harding CL, Quach D, Sugie J, Pogliano J, Parish T.Antimicrob Agents Chemother. 2025 Sep 22:e0098025. doi: 10.1128/aac.00980-25. Online ahead of print.PMID: 40980915  

  

Structure-Activity Relationship Study of Benzamides as Mycobacterium tuberculosis QcrB Inhibitors. 

Lynde BE, Mattos J, Chemaly DM, Deshpande A, Pogula SR, Greve E, Chowdhury S, Parish T.ACS Med Chem Lett. 2025 Jul 3;16(8):1610-1618. doi: 10.1021/acsmedchemlett.5c00252. eCollection 2025 Aug 14.PMID: 40832552 

  

Evaluation of an AI-Assisted Platform to Support Tuberculosis Care Delivery. 

Iribarren S, Yuwen W, Filienko D, Jakher H, Nizar M, Vidrio A, Kwanin C, Galdamez D, Roberti J, De Cock M.Stud Health Technol Inform. 2025 Aug 7;329:1550-1552. doi: 10.3233/SHTI251099.PMID: 40776117 

  

Scaffold Hopping Strategy toward New 4Aminoquinazolines Active Against Extracellular and Intracellular. 

Gonçalves GA, de Matos Czeczot A, Perelló MA, Greve E, Allen R, Zotti CZ, González LC, Berger A, Paz JD, Oliveira LK, E Silva SM, Bizarro CV, Basso LA, Parish T, Machado P.ACS Med Chem Lett. 2025 Jun 30;16(7):1410-1419. doi: 10.1021/acsmedchemlett.5c00276. eCollection 2025 Jul 10.PMID: 40666484 

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Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity. 

Meade RK, Adefisayo OO, Gontijo MTP, Harris SJ, Pyle CJ, Wilburn KM, Ecker AMV, Hughes EJ, Garcia PD, Ivie J, McHenry ML, Benchek PH, Mayanja-Kizza H, Neff JL, Ko DC, Stout JE, Stein CM, Hawn TR, Tobin DM, Smith CM.PLoS Biol. 2025 Sep 9;23(9):e3003377. doi: 10.1371/journal.pbio.3003377. eCollection 2025 Sep.PMID: 40924769  

  

Microbiological evidence for the trisubstituted benzimidazoles targeting MmpL3 in Mycobacterium tuberculosis. 

Zhang M, Allen R, Ames L, Engelhart CA, Quach D, Lv X, Xiao G, Wang H, Wang J, Zhou L, Pan M, Sugie J, Pogliano J, Schnappinger D, Parish T, Chen S.Antimicrob Agents Chemother. 2025 Oct;69(10):e0036825. doi: 10.1128/aac.00368-25. Epub 2025 Aug 19.PMID: 40827962 

  

User-Centered Refinement of a Digital Tool for Tuberculosis Treatment Support: Iterative Mixed Methods Study. 

Iribarren S, Aguilar Vidrio OA, Roberti J, Goodwin K, Chirico C, Telles H, Lutz B, Bornengo F, Rubinstein F.J Med Internet Res. 2025 Jul 30;27:e76742. doi: 10.2196/76742.PMID: 40737522 

 

A mixed-method study to inform the design of a video observed therapy app to monitor individuals with TB in the Dominican Republic. 

Canario-Guzmán JA, Elias-Melgen R, Mendoza ER, Arias LF, Espinal R, Báez J, Iribarren S.Front Public Health. 2025 Jun 6;13:1529687. doi: 10.3389/fpubh.2025.1529687. eCollection 2025.PMID: 40547466  

  

Usability and acceptability of a novel TB infection diagnostic test among key populations in Mexicali. 

Brumwell A, Herrera R, Contreras K, Lee M, Becerra E, Estrada-Guzmán J, Nicholson T, Contreras RM, Brooks M.PLOS Glob Public Health. 2025 Aug 25;5(8):e0005042. doi: 10.1371/journal.pgph.0005042. eCollection 2025.PMID: 40853936 Free PMC article. 

  

Assessing tuberculosis infection prevalence and test concordance in high-risk groups: a cross-sectional study in Mexicali, Baja California. 

Brumwell A, Herrera R, Contreras K, Lee M, Becerra E, Estrada-Guzmán J, Nicholson T, Machado Contreras R, Brooks MB.BMJ Open. 2025 Sep 14;15(9):e097505. doi: 10.1136/bmjopen-2024-097505.PMID: 40953864 Free PMC article. 

  

Identifying gaps in tuberculosis preventive care for non-U.S.-born persons at community health clinics in the United States. 

Shete PB, Murrill MT, Tatum KM, Ahmed A, Aiona K, Aldous JL, Flood J, Haas MK, Narita M, Pettit AC, Séraphin MN, Cattamanchi A, Ayers TL.medRxiv [Preprint]. 2025 Jun 24:2025.06.24.25330215. doi: 10.1101/2025.06.24.25330215.PMID: 40666372 Free PMC article. Preprint. 

  

Enhancing tuberculosis treatment support: A thematic analysis of interactive messages in a digital adherence technology trial to identify needs, challenges, and strategies for improvement. 

Roberti J, Carmiol-Rodríguez P, Chan-Liang E, Aguilar-Vidrio OA, Suyanto AA, Sprecher J, Rubinstein F, Iribarren S.PLoS One. 2025 Jul 24;20(7):e0326492. doi: 10.1371/journal.pone.0326492. eCollection 2025.PMID: 40705794 Free PMC article. Clinical Trial. 

  

Early structural cardiovascular disease, HIV, and tuberculosis in East Africa (ASANTE): cross-sectional study protocol for a multimodal cardiac imaging study in Nairobi, Kenya. 

Shakil SS, Korir S, Omondi G, Ale BM, Gitura B, Morris M, Kinuthia J, Chohan B, Haynes N, Farquhar C, Hsue PY, Longenecker CT, Osoti A.BMJ Open. 2025 Jul 11;15(7):e102684. doi: 10.1136/bmjopen-2025-102684.PMID: 40645628 Free PMC article. 

  

The unintended outcome: a retrospective cross-sectional study using a urine lateral flow assay to detect ART use reveals non-disclosure of taking ART in South Africa's public health system. 

Sithole N, Govender I, Spinelli M, Smit T, Cibane S, Zwane M, Phakathi N, Krows M, Nkosi B, Seeley J, Barnabas RV, Siedner MJ, Moshabela M, Celum C, Grant A, Gandhi M, Shapiro AE.J Int AIDS Soc. 2025 Jun;28(6):e26515. doi: 10.1002/jia2.26515.PMID: 40551583 Free PMC article. 

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Improving tuberculosis treatment adherence: a qualitative study of patients' perspectives from a pragmatic trial of the tuberculosis treatment support tools intervention. 

Roberti J, Morelli DM, Aguilar-Vidrio OA, Suyanto A, Carmiol-Rodriguez P, Tolentino A, Chen-Liang E, Sprecher J, Rubinstein F, Iribarren S.BMJ Open. 2025 Sep 2;15(9):e095878. doi: 10.1136/bmjopen-2024-095878.PMID: 40897502 Free PMC article. Clinical Trial. 

  

Epidemiological factors associated with immunological resistance in household contacts exposed to active tuberculosis in South Africa: A logistic regression analysis. 

Maenetje N, Oladimeji M, Mlotshwa M, Hoft D, Lindan C, Wallis R, Charalambous S, Churchyard G, Edward V, Fiore-Gartland A, Shai J, Maenetje P.PLoS One. 2025 Aug 19;20(8):e0329562. doi: 10.1371/journal.pone.0329562. eCollection 2025.PMID: 40828791 Free PMC article. 

January - April 2025

 Novel 3-Aminothieno[2,3-b]pyridine-2-carboxamides with Activity against Mycobacterium tuberculosis.

Lynde BE, Chemaly DM, Baldin VP, Greve E, Harding CL, Graner JM, Hardy M, Chowdhury S, Parish T.ACS Med Chem Lett. 2025 Jan 3;16(2):241-249. doi: 10.1021/acsmedchemlett.4c00472. eCollection 2025 Feb 13.PMID: 39967629 Free PMC article.

 

 Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review.

Chihota V, Gombe M, Gupta A, Salazar-Austin N, Ryckman T, Hoffmann CJ, LaCourse S, Mathad JS, Mave V, Dooley KE, Chaisson RE, Churchyard G.Drugs. 2025 Feb;85(2):127-147. doi: 10.1007/s40265-024-02131-3. Epub 2024 Dec 28.PMID: 39733063 Free PMC article. Review.

 

 Mobility patterns, activity locations, and TB in Nairobi, Kenya.

Tram KH, Ong'ang'o J, Kiplimo R, Hawn TR, Nduba V, Horne DJ, Ross JM.Int J Tuberc Lung Dis. 2025 Mar 1;29(3):103-112. doi: 10.5588/ijtld.24.0372.PMID: 40052657

 Persistently high TB prevalence in Nairobi County neighbourhoods, 2015-2022.

Ong'ang'o JR, Ross J, Kiplimo R, Kerama C, Tram KH, Zifodya JS, Mukiri N, Nyadimo E, Njoroge M, Ronoh A, Kathure I, Kirathe D, Hawn TR, Nduba V, Horne DJ.PLOS Glob Public Health. 2025 Feb 18;5(2):e0003849. doi: 10.1371/journal.pgph.0003849. eCollection 2025.PMID: 39965017 Free PMC article.

 High-dose intravenous BCG vaccination induces enhanced immune signaling in the airways.

Peters JM, Irvine EB, Makatsa MS, Rosenberg JM, Wadsworth MH 2nd, Hughes TK, Sutton MS, Nyquist SK, Bromley JD, Mondal R, Roederer M, Seder RA, Darrah PA, Alter G, Seshadri C, Flynn JL, Shalek AK, Fortune SM, Bryson BD.Sci Adv. 2025 Jan 3;11(1):eadq8229. doi: 10.1126/sciadv.adq8229. Epub 2025 Jan 1.PMID: 39742484 Free PMC article.

 Evaluation of host immune responses to Mycobacteriophage Fionnbharth by route of delivery.

Smytheman T, Pecor T, Miller DE, Ferede D, Kaur S, Harband MH, Abdelaal HFM, Guerrero-Bustamante CA, Freeman KG, Harrington WE, Frenkel LM, Hatfull GF, Coler RN, Larsen SE.Virol J. 2025 Jan 20;22(1):14. doi: 10.1186/s12985-024-02552-2.PMID: 39833928 Free PMC article.

 Deep learning-driven bacterial cytological profiling to determine antimicrobial mechanisms in Mycobacterium tuberculosis.

Quach D, Sharp M, Ahmed S, Ames L, Bhagwat A, Deshpande A, Parish T, Pogliano J, Sugie J.Proc Natl Acad Sci U S A. 2025 Feb 11;122(6):e2419813122. doi: 10.1073/pnas.2419813122. Epub 2025 Feb 6.PMID: 39913203

 Association of Mycobacterium tuberculosis aerosolization and HIV coinfection in the index case with T cell responses in household contacts.

Njagi LN, Nduba V, Murithi WB, Mwongera Z, Cook K, Mecha J, Chacha R, Fennelly KP, Horne DJ, Hawn TR.Sci Rep. 2025 Jan 2;15(1):224. doi: 10.1038/s41598-024-83965-5.PMID: 39748008 Free PMC article.

 Pulmonary Tuberculosis Infectiousness of Persons Identified Through Active and Passive Case-finding in a High-burden Setting.

Njagi LN, Tram KH, Zifodya JS, Paul S, Ross JM, Murithi W, Mwongera Z, Kiplimo R, Ong'ang'o JR, Fennelly KP, Hawn TR, Nduba V, Horne DJ.Open Forum Infect Dis. 2025 Feb 10;12(3):ofaf077. doi: 10.1093/ofid/ofaf077. eCollection 2025 Mar.PMID: 40046891 Free PMC article.

 Within-country heterogeneity in patterns of social contact relevant for tuberculosis infection transmission, prevention, and care.

LeGrand KE, Edwards A, Mohlamonyane M, Dayi N, Olivier S, Gareta D, Wood R, Grant AD, White RG, Middelkoop K, Khan P, McCreesh N.medRxiv [Preprint]. 2025 Jan 22:2025.01.21.25320893. doi: 10.1101/2025.01.21.25320893.PMID: 39974087 Free PMC article. Preprint.

 Author Correction: Association of Mycobacterium tuberculosis aerosolization and HIV coinfection in the index case with T cell responses in household contacts.

Njagi LN, Nduba V, Murithi WB, Mwongera Z, Cook K, Mecha J, Chacha R, Fennelly KP, Horne DJ, Hawn TR.Sci Rep. 2025 Feb 27;15(1):7085. doi: 10.1038/s41598-025-90994-1.PMID: 40016444 Free PMC article. No abstract available.

 Diminished Mycobacterium tuberculosis-specific T-cell Responses During Pregnancy in Women With HIV and Receiving Isoniazid Preventive Therapy.

Saha A, Escudero JN, Layouni T, Mecha J, Maleche-Obimbo E, Matemo D, Kinuthia J, John-Stewart G, Richardson BA, LaCourse SM, Shah JA.Open Forum Infect Dis. 2025 Feb 5;12(2):ofaf067. doi: 10.1093/ofid/ofaf067. eCollection 2025 Feb.PMID: 39981072 Free PMC article.

 

 Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent.

Painter H, Larsen SE, Williams BD, Abdelaal HFM, Baldwin SL, Fletcher HA, Fiore-Gartland A, Coler RN.mSphere. 2025 Jan 28;10(1):e0086424. doi: 10.1128/msphere.00864-24. Epub 2024 Dec 9.PMID: 39651886 Free PMC article.

 

 Diagnostic accuracy of self-collected tongue swabs for Mycobacterium tuberculosis complex detection in individuals being assessed for tuberculosis in South Africa using the Xpert MTB/RIF Ultra assay.

David A, Singh L, Peloakgosi-Shikwambani K, Nsingwane Z, Molepo V, Cangelosi G, da Silva P, Stevens W, Scott L.Clin Microbiol Infect. 2025 Jan 28:S1198-743X(25)00037-0. doi: 10.1016/j.cmi.2025.01.029. Online ahead of print.PMID: 39884504 Free article.

 

July-September 2024

Probing Dermal Immunity to Mycobacteria through a Controlled Human Infection Model.

Church EC, Bishop E, Fiore-Gartland A, Yu KKQ, Chang M, Jones RM, Brache JK, Ballweber Fleming L, Phan JM, Makatsa MS, Heptinstall J, Chiong K, Dintwe O, Naidoo A, Voillet V, Mayer-Blackwell K, Nwanne G, Andersen-Nissen E, Vary JC Jr, Tomaras GD, McElrath MJ, Sherman DR, Murphy SC, Kublin JG, Seshadri C. Immunohorizons. 2024 Sep 1;8(9):695-711. doi: 10.4049/immunohorizons.2400053.PMID: 39283647 Clinical Trial.

Mycobacterium tuberculosis cough aerosol culture status associates with host characteristics and inflammatory profiles.

Nduba V, Njagi LN, Murithi W, Mwongera Z, Byers J, Logioia G, Peterson G, Segnitz RM, Fennelly K, Hawn TR, Horne DJ. Nat Commun. 2024 Sep 1;15(1):7604. doi: 10.1038/s41467-024-52122-x.PMID: 39217183 

Developing an AI-Assisted Platform to Support Tuberculosis Care Delivery.

Iribarren S, Yuwen W, de Cock M. Stud Health Technol Inform. 2024 Aug 22;316:839-840. doi: 10.3233/SHTI240542.PMID: 39176923

Adapting a Patient-Centered Tuberculosis Digital Adherence Technology Intervention for New Patient Populations.

Suyanto A, Iribarren S, Turner AM. Stud Health Technol Inform. 2024 Aug 22;316:228-229. doi: 10.3233/SHTI240386.PMID: 39176715

Epigenetic programming of host lipid metabolism associated with resistance to TST/IGRA conversion after exposure to Mycobacterium tuberculosis.

Dill-McFarland KA, Simmons JD, Peterson GJ, Nguyen FK, Campo M, Benchek P, Stein CM, Vaisar T, Mayanja-Kizza H, Boom WH, Hawn TR. mSystems. 2024 Sep 17;9(9):e0062824. doi: 10.1128/msystems.00628-24. Epub 2024 Aug 20.PMID: 39162406 

Isoniazid preventive therapy during infancy does not adversely affect growth among HIV-exposed uninfected children: Secondary analysis of data from a randomized controlled trial.

Cherkos AS, LaCourse SM, Enquobahrie DA, Escudero JN, Mecha J, Matemo D, Kinuthia J, Iribarren SJ, John-Stewart G.PLoS One. 2024 Aug 16;19(8):e0293708. doi: 10.1371/journal.pone.0293708. eCollection 2024.PMID: 39150949 Clinical Trial.

Optimizing Directed Research Groups with Students to Iteratively Refine the Tuberculosis Treatment Support Tools.

Iribarren S, Vidrio AA.Stud Health Technol Inform. 2024 Jul 24;315:180-184. doi: 10.3233/SHTI240130.PMID: 39049249

A successful UN High-Level Meeting on antimicrobial resistance must build on the 2023 UN High-Level Meeting on tuberculosis.

Cirillo D, Anthony R, Gagneux S, Horsburgh CR Jr, Hasan R, Darboe S, Laniado-Laborin R, Probandari A, Tukvadze N, Arcêncio RA, Bimba JS, Brighenti S, Chesov D, Chiang CY, Kalmambetova G, Knight G, Konstantynovska O, Kruse A, Lange C, Mayanja-Kizza H, McBryde E, Min J, Sanchez-Montalva A, Sulis G, Tsogt B, Van Der Walt M, Yeboah-Manu D, Hauser J. Lancet Glob Health. 2024 Aug;12(8):e1225-e1226. doi: 10.1016/S2214-109X(24)00229-8.PMID: 39030054 

Development of tuberculosis treatment decision algorithms in children below 5 years hospitalised with severe acute malnutrition in Zambia and Uganda: a prospective diagnostic cohort study.

Chabala C, Roucher C, Ton Nu Nguyet MH, Babirekere E, Inambao M, Businge G, Kapula C, Shankalala P, Nduna B, Mulenga V, Graham S, Wobudeya E, Bonnet M, Marcy O; TB-Speed SAM study group. EClinicalMedicine. 2024 Jun 20;73:102688. doi: 10.1016/j.eclinm.2024.102688. eCollection 2024 Jul.PMID: 39007063 

Specific CD4+ T cell phenotypes associate with bacterial control in people who 'resist' infection with Mycobacterium tuberculosis.

Sun M, Phan JM, Kieswetter NS, Huang H, Yu KKQ, Smith MT, Liu YE, Wang C, Gupta S, Obermoser G, Maecker HT, Krishnan A, Suresh S, Gupta N, Rieck M, Acs P, Ghanizada M, Chiou SH, Khatri P, Boom WH, Hawn TR, Stein CM, Mayanja-Kizza H, Davis MM, Seshadri C. Nat Immunol. 2024 Aug;25(8):1411-1421. doi: 10.1038/s41590-024-01897-8. Epub 2024 Jul 12.PMID: 38997431 

The inclusion of children and adolescents in tuberculosis diagnostic development and evaluation-a consensus statement.

Bijker EM, Horn L, LaCourse S, MacLean EL, Marais BJ, Nicol MP, Olbrich L, Seddon JA, Sutherland JS, Song R, Zar HJ, Jaganath D; Child TB Diagnostics Consensus Group. Lancet Infect Dis. 2024 Jul 3:S1473-3099(24)00339-6. doi: 10.1016/S1473-3099(24)00339-6. Online ahead of print.PMID: 38971177 Review. 

Attenuated tuberculin skin test responses associated with Mycobacterium intracellulare sputum colonization in an adolescent TB prevalence survey in Western Kenya.

Njagi LN, Kaguthi G, Mecha JO, Hawn TR, Nduba V. Tuberculosis (Edinb). 2024 Jul;147:102514. doi: 10.1016/j.tube.2024.102514. Epub 2024 May 5.PMID: 38723342

April-June 2024

Mapping TB incidence across districts in Uganda to inform health program activities.

Henry NJ, Zawedde-Muyanja S, Majwala RK, Turyahabwe S, Barnabas RV, Reiner RC Jr, Moore CE, Ross JM.IJTLD Open. 2024 May 1;1(5):223-229. doi: 10.5588/ijtldopen.23.0624. eCollection 2024 May.PMID: 39022779 Free PMC article.

Host and pathogen genetic diversity shape vaccine-mediated protection to Mycobacterium tuberculosis.

Cohen SB, Plumlee CR, Engels L, Mai D, Murray TA, Jahn AN, Alexander B, Delahaye JL, Cross LM, Maciag K, Schrader S, Durga K, Gold ES, Aderem A, Gerner MY, Gern BH, Diercks AH, Urdahl KB. Front Immunol. 2024 Jun 28;15:1427846. doi: 10.3389/fimmu.2024.1427846. eCollection 2024.PMID: 39007152 Free PMC article.

Protective interplay: Mycobacterium tuberculosis diminishes SARS-CoV-2 severity through innate immune priming.

Williams BD, Ferede D, Abdelaal HFM, Berube BJ, Podell BK, Larsen SE, Baldwin SL, Coler RN. Front Immunol. 2024 Jun 20;15:1424374. doi: 10.3389/fimmu.2024.1424374. eCollection 2024.PMID: 38966641 Free PMC article. 

Airway microbiome signature accurately discriminates Mycobacterium tuberculosis infection status.

Kayongo A, Ntayi ML, Olweny G, Kyalo E, Ndawula J, Ssengooba W, Kigozi E, Kalyesubula R, Munana R, Namaganda J, Caroline M, Sekibira R, Bagaya BS, Kateete DP, Joloba ML, Jjingo D, Sande OJ, Mayanja-Kizza H. iScience. 2024 May 28;27(6):110142. doi: 10.1016/j.isci.2024.110142. eCollection 2024 Jun 21.PMID: 38904070 Free PMC article.

Adolescent BCG revaccination induces a phenotypic shift in CD4+ T cell responses to Mycobacterium tuberculosis.

Dintwe OB, Ballweber Fleming L, Voillet V, McNevin J, Seese A, Naidoo A, Omarjee S, Bekker LG, Kublin JG, De Rosa SC, Newell EW, Fiore-Gartland A, Andersen-Nissen E, McElrath MJ.Nat Commun. 2024 Jun 18;15(1):5191. doi: 10.1038/s41467-024-49050-1.PMID: 38890283 Free PMC article. Clinical Trial.

Attenuated tuberculin skin test responses associated with Mycobacterium intracellulare sputum colonization in an adolescent TB prevalence survey in Western Kenya.

Njagi LN, Kaguthi G, Mecha JO, Hawn TR, Nduba V. Tuberculosis (Edinb). 2024 Jul;147:102514. doi: 10.1016/j.tube.2024.102514. Epub 2024 May 5.PMID: 38723342 Free PMC article.

MR1-restricted T cell clonotypes are associated with "resistance" to Mycobacterium tuberculosis infection.

Cross DL, Layton ED, Yu KK, Smith MT, Aguilar MS, Li S, Wilcox EC, Chapuis AG, Mayanja-Kizza H, Stein CM, Boom WH, Hawn TR, Bradley P, Newell EW, Seshadri C. JCI Insight. 2024 May 8;9(9):e166505. doi:10.1172/jci.insight.166505.PMID: 38716731 Free PMC article. 

Capturing Recent Mycobacterium tuberculosis Infection by Tuberculin Skin Test vs. Interferon-Gamma Release Assay.

Gutierrez J, Nsereko M, Malone LL, Mayanja-Kizza H, Kisingo H, Boom WH, Bark CM, Stein CM. Trop Med Infect Dis. 2024 Apr 11;9(4):81. doi: 10.3390/tropicalmed9040081.PMID: 38668542 Free PMC article.

Age and sex influence antibody profiles associated with tuberculosis progression.

Davies LRL, Wang C, Steigler P, Bowman KA, Fischinger S, Hatherill M, Fisher M, Mbandi SK, Rodo M, Ottenhoff THM, Dockrell HM, Sutherland JS, Mayanja-Kizza H, Boom WH, Walzl G, Kaufmann SHE, Nemes E, Scriba TJ, Lauffenburger D, Alter G, Fortune SM. Nat Microbiol. 2024 Jun;9(6):1513-1525. doi: 10.1038/s41564-024-01678-x. Epub 2024 Apr 24.PMID: 38658786 Free PMC article. 

Interpreter usage and associations with latent tuberculosis infection treatment acceptance and completion in the USA among non-U.S.-born persons, 2012-2017.

Gonzalez-Reyes R, Katz D, Lambert L, Sorri Y, Narita M, Horne DJ; Tuberculosis Epidemiologic Studies Consortium.PLoS One. 2024 Apr 16;19(4):e0298628. doi: 10.1371/journal.pone.0298628. eCollection 2024.PMID: 38625902 Free PMC article.

Re-appraising the role of T-cell derived interferon gamma in restriction of Mycobacterium tuberculosis in the murine lung: T-cell derived IFNγ is required to restrict pulmonary Mtb.

Maciag K, Plumlee C, Cohen S, Gern B, Urdahl K. bioRxiv [Preprint]. 2024 Apr 5:2024.04.04.588086. doi: 10.1101/2024.04.04.588086.Update in: J Immunol. 2024 Aug 1;213(3):339-346. doi: 10.4049/jimmunol.2400145.PMID: 38617280 Free PMC article. Preprint.

Comparison of Tuberculin Skin Testing and Interferon-γ Release Assays in Predicting Tuberculosis Disease.

Ayers T, Hill AN, Raykin J, Mohanty S, Belknap RW, Brostrom R, Khurana R, Lauzardo M, Miller TL, Narita M, Pettit AC, Pyan A, Salcedo KL, Polony A, Flood J; CDC Tuberculosis Epidemiologic Studies Consortium. JAMA Netw Open. 2024 Apr 1;7(4):e244769. doi: 10.1001/jamanetworkopen.2024.4769.PMID: 38568690 Free PMC article.

Usability testing of a mobile health application to support individuals with active tuberculosis: a mixed methods study.

Stabile AJ, Iribarren S, Sonney J, Demiris G, Schnall R. Inform Health Soc Care. 2024 Apr 2;49(2):136-148. doi: 10.1080/17538157.2024.2333379. Epub 2024 Mar 26.PMID: 38529729

Jan-Mar 2024

 

Exposure to Mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection. Mai D, Jahn A, Murray T, Morikubo M, Lim PN, Cervantes MM, Pham LK, Nemeth J, Urdahl K, Diercks AH, Aderem A, Rothchild AC. PLoS Pathog. 2024 Jan 18;20(1):e1011871. doi: 10.1371/journal.ppat.1011871. eCollection 2024 Jan. PMID: 38236787 Free PMC article.

Oral swabs with a rapid molecular diagnostic test for pulmonary tuberculosis in adults and children: a systematic review. Church EC, Steingart KR, Cangelosi GA, Ruhwald M, Kohli M, Shapiro AE. Lancet Glob Health. 2024 Jan;12(1):e45-e54. doi: 10.1016/S2214-109X(23)00469-2. PMID: 38097297 Free PMC article.

Mycobacterium tuberculosis-dependent monocyte expression quantitative trait loci, cytokine production, and TB pathogenesis. Hong H, Dill-McFarland KA, Simmons JD, Peterson GJ, Benchek P, Mayanja-Kizza H, Boom WH, Stein CM, Hawn TR. Front Immunol. 2024 Mar 7;15:1359178. doi: 10.3389/fimmu.2024.1359178. eCollection 2024. PMID: 38515745 Free PMC article.

MSMEG_0918 is not Essential for the Growth of Mycobacteriumsmegmatis. Bedru E, Bhagwat A, Parish T. MicroPubl Biol. 2024 Feb 6;2024:10.17912/micropub.biology.000891. doi: 10.17912/micropub.biology.000891. eCollection 2024. PMID: 38404920 Free PMC article.

Regulatory Intersection of Two-component System and Ser/Thr Protein Kinase Signaling in Mycobacterium tuberculosis. Frando A, Boradia V, Grundner C. J Mol Biol. 2024 Jan 15;436(2):168379. doi: 10.1016/j.jmb.2023.168379. Epub 2023 Dec 1. PMID: 38043732

Tuberculosis Infectiousness is Associated with Distinct Clinical and Inflammatory Profiles. Horne D, Nduba V, Njagi L, Murithi W, Mwongera Z, Logioia G, Peterson G, Segnitz RM, Fennelly K, Hawn T. Res Sq [Preprint]. 2024 Jan 10:rs.3.rs-3722244. doi: 10.21203/rs.3.rs-3722244/v1. PMID: 38328225 Free PMC article. Preprint.

TBscreen: A passive cough classifier for tuberculosis screening with a controlled dataset. Sharma M, Nduba V, Njagi LN, Murithi W, Mwongera Z, Hawn TR, Patel SN, Horne DJ. Sci Adv. 2024 Jan 5;10(1):eadi0282. doi: 10.1126/sciadv.adi0282. Epub 2024 Jan 3. PMID: 38170773 Free PMC article.

Towards pharmacogenomics-guided tuberculosis (TB) therapy: N-acetyltransferase-2 genotypes among TB-infected Kenyans of mixed ethnicity. Njagi LN, Mecha JO, Mureithi MW, Otieno LE, Nduba V. BMC Med Genomics. 2024 Jan 6;17(1):14. doi: 10.1186/s12920-023-01788-1. PMID: 38184575 Free PMC article.

TOLLIP inhibits lipid accumulation and the integrated stress response in alveolar macrophages to control Mycobacterium tuberculosis infection. Venkatasubramanian S, Plumlee CR, Dill-McFarland KA, Cohen SB, Gern BH, Rane DA, Meyer MK, Saha A, Hinderstein SA, Pearson GL, Lietzke AC, Pacheco A, Chow YH, Hung CF, Soleimanpour SA, Altman M, Urdahl KB, Shah JA. Nat Microbiol. 2024 Apr;9(4):949-963. doi: 10.1038/s41564-024-01641-w. Epub 2024 Mar 25. PMID: 38528148

Biomarker-confirmed suboptimal adherence to isoniazid preventive therapy among children with HIV in western Kenya. Onyango DO, van der Sande MAB, Yuen CM, Were J, Mecha J, Njagi LN, Panpradist N, Matemo D, Leon D, Lutz B, Kinuthia J, John-Stewart G, Lacourse SM. AIDS. 2024 Jan 1;38(1):39-47. doi: 10.1097/QAD.0000000000003719. Epub 2023 Sep 28. PMID: 37773037

Usability testing of a mobile health application to support individuals with active tuberculosis: a mixed methods study. Stabile AJ, Iribarren S, Sonney J, Demiris G, Schnall R. Inform Health Soc Care. 2024 Mar 26:1-13. doi: 10.1080/17538157.2024.2333379. Online ahead of print. PMID: 38529729

Effect of tuberculosis-HIV co-treatment on clinical and growth outcomes among hospitalized children newly initiating antiretroviral therapy. Cherkos AS, Cranmer LM, Njuguna I, LaCourse SM, Mugo C, Moraa H, Maleche-Obimbo E, Enquobahrie DA, Richardson BA, Wamalwa D, John-Stewart G. AIDS. 2024 Mar 15;38(4):579-588. doi: 10.1097/QAD.0000000000003797. Epub 2023 Nov 27. PMID: 38016160

Maternal HIV Status and Risk of Infant Mycobacterium tuberculosis Infection as Measured by Tuberculin Skin Test. Mecha J, Escudero JN, Richardson BA, Maleche-Obimbo E, Matemo D, Kinuthia J, John-Stewart G, LaCourse SM. Pediatr Infect Dis J. 2024 Mar 1;43(3):250-256. doi: 10.1097/INF.0000000000004190. Epub 2023 Nov 22. PMID: 37991383

Molecular detection of pre-ribosomal RNAs of Mycobacterium bovis bacille Calmette-Guérin and Mycobacterium tuberculosis to enhance pre-clinical tuberculosis drug and vaccine development. Chang M, Venkatasubramanian S, Barrett H, Urdahl KB, Weigel KM, Cangelosi GA, Shah JA, Saha A, Feng L, Adams KN, Sherman DR, Smith N, Seshadri C, Kublin JG, Murphy SC. Diagn Microbiol Infect Dis. 2024 Jan;108(1):116106. doi: 10.1016/j.diagmicrobio.2023.116106. Epub 2023 Oct 16. PMID: 37931386 Free PMC article.

Epigenetic programming of host lipid metabolism associates with resistance to TST/IGRA conversion after exposure to Mycobacterium tuberculosis. Dill-McFarland KA, Simmons JD, Peterson GJ, Nguyen FK, Campo M, Benchek P, Stein CM, Vaisar T, Mayanja-Kizza H, Boom WH, Hawn TR. bioRxiv [Preprint]. 2024 Mar 4:2024.02.27.582348. doi: 10.1101/2024.02.27.582348. PMID: 38464296 Free PMC article. Preprint.

Interpreter usage and associations with latent tuberculosis infection treatment acceptance and completion in the USA among non-U.S.-born persons, 2012-2017. Gonzalez-Reyes R, Katz D, Lambert L, Sorri Y, Narita M, Horne DJ; Tuberculosis Epidemiologic Studies Consortium. PLoS One. 2024 Apr 16;19(4):e0298628. doi: 10.1371/journal.pone.0298628. eCollection 2024. PMID: 38625902 Free PMC article.

Maternal breastfeeding and education impact infant growth and development more than in-utero HIV/antiretroviral therapy exposure in context of universal antiretroviral therapy. Cherkos AS, LaCourse SM, Kinuthia J, Mecha J, Enquobahrie DA, Escudero JN, John-Stewart G. AIDS. 2024 Mar 15;38(4):537-546. doi: 10.1097/QAD.0000000000003785. Epub 2023 Nov 14. PMID: 37967230

Diagnostic accuracy of tongue swab testing on two automated tuberculosis diagnostic platforms, Cepheid Xpert MTB/RIF Ultra and Molbio Truenat MTB Ultima. Wood RC, Luabeya AK, Dragovich RB, Olson AM, Lochner KA, Weigel KM, Codsi R, Mulenga H, de Vos M, Kohli M, Penn-Nicholson A, Hatherill M, Cangelosi GA. J Clin Microbiol. 2024 Apr 10;62(4):e0001924. doi: 10.1128/jcm.00019-24. Epub 2024 Mar 14. PMID: 38483169 Free PMC article.